Potentiation of 5-Fluorouracil, Chromomycin A3, and Bleomycin by Amphotericin B or Polymyxin B in Transformed Fibroblastic Cells
نویسندگان
چکیده
منابع مشابه
Potentiation of rifampicin, rifampicin analogs, and tetracycline against animal cells by amphotericin B and polymyxin B.
A number of antibiotics alter the permeability of the membranes of eukaryotic cells (1). Previously, we have exploited this property of amphotericin B to increase the uptake of 2nd drugs into fungi and animal cells, thereby enhancing the effects of the 2nd agents (5—7). Recently our studies have been confirmed by Kuwano et al. (4). This report is an extension of our previous work and represen...
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The biosynthesis of chromomycin A3 was investigated using 13C-labeled acetates, methionine and glucose, and 13C,18O-labeled acetate. 13C NMR spectral analysis demonstrated that: Aglycone assembly occurs by combining at least two polyketide chains; three of nine oxygen atoms of the aglycone originate from acetate precursor oxygen atoms; carbon methylations on the aromatic ring at C-7, on the chr...
متن کاملPotentiation of bleomycin by an antifungal polyene, pentamycin, in transformed animal cells.
dine@4C (50 @.tCi/230 .tg; New England Nuclear, Boston, Mass.), and thymidine-3H (20 Ci/mmole; New England Nuclear) were used as isotopes. 5-Fluorouracil (Kyowa Hakko Ind. Co., Tokyo, Japan), fusidic acid (Sankyo md. Co., Tokyo, Japan), and a-amanitin (Lot A 32778; Boehringen/Mannheim, Mannheim, Germany) were used for the study of synergism. Bleomycin A2 was a gift from H. Umezawa. Amphotenicin...
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Amphotericin B deoxycholate (AmB) or Amphotericin B colloidal dispersion (ABCD) are used in clinics for the treatment of systemic fungal infections. The goal of our study was to compare the nephrotoxicity of these drugs in rat kidney. The effects of AmB and ABCD on the ultrastructure of the epithelium of renal tubules were studied and evaluated using morphometric and statistical methods. Two gr...
متن کاملSensitivity of transformed and nontransformed cells to amphotericin B and several rifamycin derivatives.
SUMMARY Probable synergy has been demonstrated for the com binations of amphotercin B and each of several nifamycin Sv derivatives against nontransformed BALB/3T3 cells and cells transformed with munine sarcoma virus. Synergy also appeared to be present for the combinations of am photericin B and dimethyl formamide on ethanol. The transformed cells were more sensitive to the com binations than ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1973
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.3.5.580